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KMID : 0614620010370020128
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Korean Journal of Gastroenterology
2001 Volume.37 No. 2 p.128 ~ p.131
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A Case of Famotidine-associated Delirium
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이강문/Kang Moon Lee
김상우/이동수/송호진/양영상/채현석/안병민/정인식/박두호/Sang Woo Kim/Dong Soo Lee/Ho Jin Song/Young Sang Yang/Hiun Seok Chae/Byung Min Ahn/In Sik Chung/Doo Ho Park
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Abstract
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The use of histamine (H2)-receptor blockers has been associated with central nervous system (CNS) toxicities manifesting as delirium, mental confusion, dizziness, and hallucination. Elderly patients with renal or hepatic dysfunction
are
more
susceptible to these adverse reactions. Most of these reactions have been reported with both cimetidine and ranitidine. Famotidine, one of H2 blockers, has been shown to be effective in improving symptoms and healing gastrointestinal
lesions.
Since 1986, an estimated 18.8 million worldwide patients have been treated with famotidine, but CNS adverse reactions associated with famotidine have been reported very rarely. The authors report a case of famotidine-associated delirium in an
elderly
patient with mild renal insufficiency, which was cleared completely after stopping the administration of famotidine.
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